Bioidentical Hormone Replacement Therapy (BHRT)

Compounded progesterone capsules provide micronized, bioidentical progesterone, meaning it has the same chemical structure as the progesterone your body makes. It is a core part of bioidentical hormone replacement therapy (BHRT) for menopause and perimenopause. Its most important role is to balance estrogen: for women with a uterus who take estrogen, progesterone protects the uterine lining, lowering the risk of the abnormal thickening (endometrial hyperplasia) that unopposed estrogen can cause.

Progesterone does more than protect the lining. Taken by mouth, it is processed into calming byproducts (like allopregnanolone) that act on the brain's GABA receptors, which is why many women find it improves sleep and eases anxiety and mood when taken at bedtime. It is used for menopausal and perimenopausal symptoms as part of a hormone plan. Because it is compounded, we can prepare progesterone in the exact strength your prescriber chooses, and in a base free of peanut oil, which the brand product uses.

Micronized progesterone is FDA-approved (as Prometrium) and considered bioidentical. It is generally well tolerated; the most common effects are drowsiness and dizziness, which is why it is usually taken at bedtime, along with possible breast tenderness or mood changes that often ease over time. Use it under a prescriber who tailors your hormone plan and monitoring. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.

Frequently asked questions

What is compounded progesterone used for?
As part of bioidentical hormone therapy for menopause and perimenopause, mainly to protect the uterine lining when taking estrogen, and to help with sleep, mood, and related symptoms.

Why take progesterone with estrogen?
For women with a uterus, estrogen alone can cause the uterine lining to thicken abnormally. Progesterone balances this and protects the lining, lowering the risk of endometrial problems.

Does progesterone help with sleep?
Oral progesterone is processed into calming byproducts that act on GABA receptors in the brain, which is why many women find it improves sleep and eases anxiety when taken at bedtime.

Is it bioidentical?
Yes. Micronized progesterone has the same structure as the progesterone your body produces. The active ingredient is FDA-approved (as Prometrium), and we compound it in your prescriber's chosen strength and a peanut-oil-free base.

Are there side effects?
It is generally well tolerated. The most common are drowsiness and dizziness, so it is usually taken at night, and sometimes breast tenderness or mood changes that often improve over time. Use under a prescriber's guidance.

New to hormone therapy? Read our full guide: our guide to bioidentical hormone therapy for menopause.

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