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Compounded bremelanotide (PT-141) nasal spray is a prescription therapy used to support sexual desire and arousal in both women and men. Unlike medications such as sildenafil (Viagra) or tadalafil (Cialis) that work on blood flow, bremelanotide works centrally. It activates melanocortin receptors (MC3R and MC4R) in the brain that help regulate sexual desire, so it targets libido and arousal itself rather than circulation. That different mechanism is why some patients turn to it when blood-flow medications alone have not been enough.
Bremelanotide is the active ingredient in Vyleesi, the FDA-approved treatment for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, where it is given as a subcutaneous injection. As a compounded medication, we prepare bremelanotide as a needle-free nasal spray in strengths set by your prescriber, an option many patients find more convenient. It is used by women for low desire and off-label by men for low libido and arousal, always under a prescriber's direction. Compounded formulations are prepared to your individual prescription and are not FDA-approved products.
Bremelanotide is generally used on an as-needed basis before intimacy, following your prescriber's instructions. The most commonly reported effects include nausea, flushing, and headache, and it can cause a temporary rise in blood pressure, so it should be used under medical supervision. Every preparation is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
What is PT-141 nasal spray used for?
It is used to support sexual desire and arousal. Bremelanotide is FDA-approved (as Vyleesi) for low sexual desire in premenopausal women, and is also used off-label for low libido in men.
How is PT-141 different from Viagra or Cialis?
Sildenafil and tadalafil work on blood flow to help with erections. PT-141 works in the brain to increase desire and arousal, so it addresses libido rather than circulation. Some prescribers use it when blood-flow medications alone have not worked.
Is compounded bremelanotide the same as Vyleesi?
It contains the same active ingredient, bremelanotide. Vyleesi is an FDA-approved subcutaneous injection. Our compounded nasal spray is prepared by a licensed pharmacy in a needle-free form and custom strength, and is not an FDA-approved product.
Can men use PT-141?
Yes. While the FDA-approved indication is for premenopausal women, prescribers commonly direct off-label use in men for low libido and arousal based on individual clinical judgment.
What are the side effects?
The most common are nausea, flushing, and headache. It can also cause a temporary increase in blood pressure. Because of this, it should be used under the guidance of a licensed prescriber.
New to PT-141? Read our full guide: how compounded bremelanotide (PT-141) nasal spray works, results and side effects.
Patients? Request More Information Prescribers? Request Prescribing Access
Compounded bremelanotide (PT-141) nasal spray is a prescription therapy used to support sexual desire and arousal in both women and men. Unlike medications such as sildenafil (Viagra) or tadalafil (Cialis) that work on blood flow, bremelanotide works centrally. It activates melanocortin receptors (MC3R and MC4R) in the brain that help regulate sexual desire, so it targets libido and arousal itself rather than circulation. That different mechanism is why some patients turn to it when blood-flow medications alone have not been enough.
Bremelanotide is the active ingredient in Vyleesi, the FDA-approved treatment for acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women, where it is given as a subcutaneous injection. As a compounded medication, we prepare bremelanotide as a needle-free nasal spray in strengths set by your prescriber, an option many patients find more convenient. It is used by women for low desire and off-label by men for low libido and arousal, always under a prescriber's direction. Compounded formulations are prepared to your individual prescription and are not FDA-approved products.
Bremelanotide is generally used on an as-needed basis before intimacy, following your prescriber's instructions. The most commonly reported effects include nausea, flushing, and headache, and it can cause a temporary rise in blood pressure, so it should be used under medical supervision. Every preparation is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
What is PT-141 nasal spray used for?
It is used to support sexual desire and arousal. Bremelanotide is FDA-approved (as Vyleesi) for low sexual desire in premenopausal women, and is also used off-label for low libido in men.
How is PT-141 different from Viagra or Cialis?
Sildenafil and tadalafil work on blood flow to help with erections. PT-141 works in the brain to increase desire and arousal, so it addresses libido rather than circulation. Some prescribers use it when blood-flow medications alone have not worked.
Is compounded bremelanotide the same as Vyleesi?
It contains the same active ingredient, bremelanotide. Vyleesi is an FDA-approved subcutaneous injection. Our compounded nasal spray is prepared by a licensed pharmacy in a needle-free form and custom strength, and is not an FDA-approved product.
Can men use PT-141?
Yes. While the FDA-approved indication is for premenopausal women, prescribers commonly direct off-label use in men for low libido and arousal based on individual clinical judgment.
What are the side effects?
The most common are nausea, flushing, and headache. It can also cause a temporary increase in blood pressure. Because of this, it should be used under the guidance of a licensed prescriber.
New to PT-141? Read our full guide: how compounded bremelanotide (PT-141) nasal spray works, results and side effects.
Patients? Request More Information Prescribers? Request Prescribing Access
