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Compounded DHEA vaginal cream is a prescription treatment for the vaginal symptoms of menopause, part of what is called genitourinary syndrome of menopause (GSM). As estrogen declines with menopause, vaginal tissue can become thin, dry, and less elastic, leading to irritation and painful intercourse. DHEA (prasterone) works locally: vaginal cells convert it into small amounts of estrogen and testosterone right in the tissue, restoring moisture, thickness, and comfort, while keeping levels in the rest of the body low.
Applied vaginally, DHEA has been shown to improve vaginal dryness, tissue health, and painful intercourse, and studies find it at least as effective as vaginal estrogen. Because it acts through this local, tissue-level pathway, it is a good option for women who want relief from GSM symptoms with minimal systemic hormone exposure. The active ingredient is FDA-approved as Intrarosa, and as a compounded cream we can prepare it in the strength and base your prescriber selects, often applied nightly and then adjusted.
DHEA vaginal cream is generally well tolerated; the most commonly reported effect is vaginal discharge from the cream base. It is used under a prescriber who can confirm it is right for you, including reviewing your personal history. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
What is DHEA vaginal cream used for?
Treating the vaginal symptoms of menopause (genitourinary syndrome of menopause): dryness, irritation, thinning tissue, and painful intercourse.
How does vaginal DHEA work?
Vaginal cells convert DHEA (prasterone) locally into small amounts of estrogen and testosterone, restoring moisture and tissue health where it is applied, with minimal hormone reaching the rest of the body.
How is it different from vaginal estrogen?
Both treat GSM effectively. DHEA works through a local, tissue-level pathway and produces both estrogen and androgen effects, and studies find it at least as effective as vaginal estrogen. Your prescriber can help you choose.
How is it used?
It is applied vaginally, usually nightly to start, on the schedule your prescriber sets. The active ingredient is FDA-approved as Intrarosa, and we compound it in the strength your prescriber selects.
Are there side effects?
It is generally well tolerated. The most common is vaginal discharge from the cream base. Use under a prescriber's guidance.
New to DHEA for menopause? Read our full guide: our guide to vaginal estrogen and DHEA for menopause.
Patients? Request More Information Prescribers? Request Prescribing Access
Compounded DHEA vaginal cream is a prescription treatment for the vaginal symptoms of menopause, part of what is called genitourinary syndrome of menopause (GSM). As estrogen declines with menopause, vaginal tissue can become thin, dry, and less elastic, leading to irritation and painful intercourse. DHEA (prasterone) works locally: vaginal cells convert it into small amounts of estrogen and testosterone right in the tissue, restoring moisture, thickness, and comfort, while keeping levels in the rest of the body low.
Applied vaginally, DHEA has been shown to improve vaginal dryness, tissue health, and painful intercourse, and studies find it at least as effective as vaginal estrogen. Because it acts through this local, tissue-level pathway, it is a good option for women who want relief from GSM symptoms with minimal systemic hormone exposure. The active ingredient is FDA-approved as Intrarosa, and as a compounded cream we can prepare it in the strength and base your prescriber selects, often applied nightly and then adjusted.
DHEA vaginal cream is generally well tolerated; the most commonly reported effect is vaginal discharge from the cream base. It is used under a prescriber who can confirm it is right for you, including reviewing your personal history. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
What is DHEA vaginal cream used for?
Treating the vaginal symptoms of menopause (genitourinary syndrome of menopause): dryness, irritation, thinning tissue, and painful intercourse.
How does vaginal DHEA work?
Vaginal cells convert DHEA (prasterone) locally into small amounts of estrogen and testosterone, restoring moisture and tissue health where it is applied, with minimal hormone reaching the rest of the body.
How is it different from vaginal estrogen?
Both treat GSM effectively. DHEA works through a local, tissue-level pathway and produces both estrogen and androgen effects, and studies find it at least as effective as vaginal estrogen. Your prescriber can help you choose.
How is it used?
It is applied vaginally, usually nightly to start, on the schedule your prescriber sets. The active ingredient is FDA-approved as Intrarosa, and we compound it in the strength your prescriber selects.
Are there side effects?
It is generally well tolerated. The most common is vaginal discharge from the cream base. Use under a prescriber's guidance.
New to DHEA for menopause? Read our full guide: our guide to vaginal estrogen and DHEA for menopause.
Patients? Request More Information Prescribers? Request Prescribing Access
