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Compounded low dose naltrexone (LDN) is a prescription capsule used off-label to help calm inflammation and modulate the immune system. Naltrexone itself is an FDA-approved medication used at higher doses (around 50 mg) for opioid and alcohol dependence. At the much lower doses used here, typically about 1.5 to 4.5 mg, it works differently. A brief, low-level blockade of opioid receptors is thought to prompt the body to increase its own endorphins, and low dose naltrexone also appears to quiet inflammatory signaling in the brain's immune cells (through a pathway called TLR-4). Together these effects can help turn down chronic inflammation and pain.
Because of these immune-modulating effects, prescribers use LDN off-label for a range of chronic conditions, including fibromyalgia, chronic pain and neuropathic pain, and autoimmune or inflammatory disorders such as Crohn's disease and multiple sclerosis. It is taken by mouth, usually once at night, and we compound it in the low, precise strengths these uses require, which are not available in standard commercial tablets.
Low dose naltrexone is used off-label under a prescriber who can find the right dose for you, and many patients report meaningful relief. It is generally well tolerated; the most commonly reported effects are vivid dreams or sleep changes, especially early on, and mild headache. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
What is low dose naltrexone used for?
Off-label for chronic inflammatory and pain conditions such as fibromyalgia, chronic and neuropathic pain, and autoimmune disorders like Crohn's disease and multiple sclerosis. It is not FDA-approved for these uses.
How does LDN work?
At low doses, a brief opioid-receptor blockade is thought to raise your own endorphins, and LDN calms inflammatory signaling in the brain's immune cells. This can reduce chronic inflammation and pain.
How is LDN different from regular naltrexone?
Regular naltrexone (about 50 mg) is FDA-approved for opioid and alcohol dependence. LDN uses a much smaller dose (about 1.5 to 4.5 mg) for a different, immune-modulating effect, and must be compounded.
How is it taken?
Usually one capsule by mouth at night, at a low dose your prescriber selects and may adjust over time.
Are there side effects?
It is generally well tolerated. The most common are vivid dreams or sleep changes early on, and occasional mild headache. Use under a prescriber's guidance.
New to LDN? Read our full guide: how low dose naltrexone works and what it may help.
Patients? Request More Information Prescribers? Request Prescribing Access
Compounded low dose naltrexone (LDN) is a prescription capsule used off-label to help calm inflammation and modulate the immune system. Naltrexone itself is an FDA-approved medication used at higher doses (around 50 mg) for opioid and alcohol dependence. At the much lower doses used here, typically about 1.5 to 4.5 mg, it works differently. A brief, low-level blockade of opioid receptors is thought to prompt the body to increase its own endorphins, and low dose naltrexone also appears to quiet inflammatory signaling in the brain's immune cells (through a pathway called TLR-4). Together these effects can help turn down chronic inflammation and pain.
Because of these immune-modulating effects, prescribers use LDN off-label for a range of chronic conditions, including fibromyalgia, chronic pain and neuropathic pain, and autoimmune or inflammatory disorders such as Crohn's disease and multiple sclerosis. It is taken by mouth, usually once at night, and we compound it in the low, precise strengths these uses require, which are not available in standard commercial tablets.
Low dose naltrexone is used off-label under a prescriber who can find the right dose for you, and many patients report meaningful relief. It is generally well tolerated; the most commonly reported effects are vivid dreams or sleep changes, especially early on, and mild headache. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
What is low dose naltrexone used for?
Off-label for chronic inflammatory and pain conditions such as fibromyalgia, chronic and neuropathic pain, and autoimmune disorders like Crohn's disease and multiple sclerosis. It is not FDA-approved for these uses.
How does LDN work?
At low doses, a brief opioid-receptor blockade is thought to raise your own endorphins, and LDN calms inflammatory signaling in the brain's immune cells. This can reduce chronic inflammation and pain.
How is LDN different from regular naltrexone?
Regular naltrexone (about 50 mg) is FDA-approved for opioid and alcohol dependence. LDN uses a much smaller dose (about 1.5 to 4.5 mg) for a different, immune-modulating effect, and must be compounded.
How is it taken?
Usually one capsule by mouth at night, at a low dose your prescriber selects and may adjust over time.
Are there side effects?
It is generally well tolerated. The most common are vivid dreams or sleep changes early on, and occasional mild headache. Use under a prescriber's guidance.
New to LDN? Read our full guide: how low dose naltrexone works and what it may help.
Patients? Request More Information Prescribers? Request Prescribing Access
