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Compounded sirolimus (rapamycin) and niacinamide cream is a prescription-only topical formulation designed to support skin rejuvenation, healthy aging, and select dermatologic conditions through complementary mechanisms that promote healthier skin function. Sirolimus inhibits the mechanistic target of rapamycin (mTOR) signaling pathway, an important regulator of cellular growth, senescence, and aging that has been investigated for its potential role in improving skin appearance, reducing features of photoaging, and supporting treatment of selected inflammatory and vascular skin disorders. Niacinamide strengthens the skin barrier, improves hydration, reduces inflammation, supports collagen production, minimizes discoloration, and enhances overall skin texture and tone. By combining these ingredients into one customized topical cream, prescribers can provide personalized skin health therapy tailored to individual patient needs. Our pharmacy compounds sirolimus and niacinamide creams in customized strengths and cosmetically elegant bases to meet dermatologist- and prescriber-directed treatment plans for skin rejuvenation and other clinically appropriate dermatologic applications.
Prescribers choose this pairing for patients focused on skin-aging support who want more than a standard moisturizer. We compound each cream to the exact strengths your prescriber specifies, in a base designed for comfortable daily use, prepared individually for each prescription.
This is a compounded medication prepared to your prescription and used under a prescriber's guidance. Your prescriber will set the concentrations and application schedule and monitor your response. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
How does this cream work?
Topical rapamycin acts on the mTOR aging pathway to support skin firmness, while niacinamide strengthens the barrier and evens tone — together targeting the look of aging skin.
What is it used for?
Prescribers use it to support skin firmness, tone, and a more youthful appearance as part of a skin-aging plan.
How is it applied?
You apply it to the skin as directed. Your prescriber sets the amount, area, and schedule.
Why compounded?
Compounding lets your prescriber tailor each ingredient's strength in a base designed for comfortable daily use, prepared fresh for each prescription.
Do I need a prescription?
Yes. This cream is compounded to your prescriber's order and requires a valid prescription. Our pharmacists prepare and verify every batch.
Patients? Request More Information Prescribers? Request Prescribing Access
Compounded sirolimus (rapamycin) and niacinamide cream is a prescription-only topical formulation designed to support skin rejuvenation, healthy aging, and select dermatologic conditions through complementary mechanisms that promote healthier skin function. Sirolimus inhibits the mechanistic target of rapamycin (mTOR) signaling pathway, an important regulator of cellular growth, senescence, and aging that has been investigated for its potential role in improving skin appearance, reducing features of photoaging, and supporting treatment of selected inflammatory and vascular skin disorders. Niacinamide strengthens the skin barrier, improves hydration, reduces inflammation, supports collagen production, minimizes discoloration, and enhances overall skin texture and tone. By combining these ingredients into one customized topical cream, prescribers can provide personalized skin health therapy tailored to individual patient needs. Our pharmacy compounds sirolimus and niacinamide creams in customized strengths and cosmetically elegant bases to meet dermatologist- and prescriber-directed treatment plans for skin rejuvenation and other clinically appropriate dermatologic applications.
Prescribers choose this pairing for patients focused on skin-aging support who want more than a standard moisturizer. We compound each cream to the exact strengths your prescriber specifies, in a base designed for comfortable daily use, prepared individually for each prescription.
This is a compounded medication prepared to your prescription and used under a prescriber's guidance. Your prescriber will set the concentrations and application schedule and monitor your response. Every batch is pharmacist-compounded, quality-verified, and shipped nationwide. Prescription required.
Frequently asked questions
How does this cream work?
Topical rapamycin acts on the mTOR aging pathway to support skin firmness, while niacinamide strengthens the barrier and evens tone — together targeting the look of aging skin.
What is it used for?
Prescribers use it to support skin firmness, tone, and a more youthful appearance as part of a skin-aging plan.
How is it applied?
You apply it to the skin as directed. Your prescriber sets the amount, area, and schedule.
Why compounded?
Compounding lets your prescriber tailor each ingredient's strength in a base designed for comfortable daily use, prepared fresh for each prescription.
Do I need a prescription?
Yes. This cream is compounded to your prescriber's order and requires a valid prescription. Our pharmacists prepare and verify every batch.
Patients? Request More Information Prescribers? Request Prescribing Access
